Next-Generation Protein Sequencing™ Made Scalable, Accessible, and Insightful
The next frontier of discovery aims to revolutionize understanding of the human proteome and explore function at the cellular level.
Next-Generation Protein Sequencing (NGPS™) reveals insights to critical questions:
- Is a specific protein present?
- Which proteins are important to health and disease?
- Why are proteins important?
- How do proteins change with disease and in response to therapy?
With Next-Generation Protein Sequencing, you can answer these critical questions quickly, right in your own lab.
Learn About Our Technology
How It Works
Prepare
Library Preparation and Sequencing Kits contain everything you need, including reagents to digest and functionalize proteins and immobilize peptides on semiconductor chips, along with aminopeptidases and recognizers to commence the sequencing process.
Sequence
Platinum Pro sequences individual peptides by capturing the fluorescent signal from each N-terminal amino acid (NAA) binding event. Aminopeptidases cleave each N-terminal amino acid, exposing the next N-terminal amino acid for recognition, and the process repeats until the whole peptide is sequenced.
Analyze
Data generated during each run is automatically uploaded to the Platinum Analysis Software. Our analysis software delivers single molecule level information about your proteins making protein identification easy to interpret without the need for bioinformatics expertise.
Kinetic Signatures
Accelerating the Path to Discovery
As Next-Generation Protein Sequencing becomes more widespread, kinetic signatures will be crucial to identifying every amino acid and every PTM, making Quantum-Si’s technology key to advancing our understanding of the proteome.
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Expand the Frontiers of Proteomics With NGPS
NGPS Differs from Mass Spectrometry
Platinum Pro is designed to fit the space, budget, and existing expertise of most labs interested in generating insights from protein sequencing data. Our technology identifies proteins using unique Kinetic Signatures based on the binding kinetics of amino acid recognition events. In contrast, mass spectrometry infers protein identification based on the mass:charge ratio which may not distinguish protein variants of similar size.
| Mass Spectrometry | Platinum | |
|---|---|---|
| Expertise | Advanced | Basic |
| Analysis | Complex | Automated |
| Lab Space | Designated Space | Benchtop Instrument |
| Startup Cost | $$$$$ | $ |
| Maintenance Cost | $$$ | $ |
Next-Generation Protein Sequencing is easy to implement and delivers answers quickly – right in your lab without the need for bioinformatics expertise.
NGPS Differs from Immunoassays
Next-Generation Protein Sequencing provides deeper insights with single-molecule resolution that, unlike immunoassays, enables assessment of what is actually happening at the amino acid level.
- Verify the specificity of your antibodies by sequencing the target protein
- Sequence the protein band from your gel
- Uncover what is there, not just what could be there
- Interrogate protein variants not resolved by antibodies
NGPS Differs from Edman Degradation
Next-Generation Protein Sequencing leverages a one-pot reaction without complex and expensive cyclical chemistry and fluidics to achieve single amino acid resolution. With NGPS, you benefit from:
- Deeper protein sequencing discoveries
- Easy protein sequencing workflows
- Affordable protein sequencing solutions