Powering the Proteomic Era
Quantum-Si, The Protein Sequencing Company™, brings the groundbreaking power of single-molecule protein sequencing to every lab, everywhere.
Platinum® Pro
An advanced Next-Generation Protein Sequencer™ delivering single-molecule resolution with real-time kinetic insights, enhanced data analysis, and a customizable user experience for variant detection and protein identification in a compact system.
Accessible Proteomics: No dedicated lab space or expertise required.
Simplified Workflow: Less than three hours of hands-on time.
Insight Generation: Direct detection of proteoforms and modifications.
User-Friendly Interface: Enlarged touchscreen for intuitive operation.
Flexible Data Analysis: Supports both local and cloud-based processing.
“This preprint highlights the potential of merging Next-Generation Protein Sequencing™ with individual ion mass spectrometry. By combining these methods, we can capture a fuller picture of IL-6 proteoforms, which is critical for advancing therapeutic innovation.”
Neil Kelleher, PhD
Professor, Northwestern University
Single-molecule Protein Sequencing Applications
Protein Barcoding
Simultaneously characterize multiple protein variants with barcoding, increasing throughput and improving efficiency in screening and therapeutic development.
High-Throughput Screening:
Evaluates multiple protein samples in parallel.
Delivery Optimization:
Enhances efficiency in LNP and AAV applications.
Cost Efficient:
Multiplex drug targets in vitro and in vivo.
Protein Identification
Achieve single-amino acid resolution for precise protein characterization, and validation in research and diagnostics.
Comprehensive Profiling:
Confirms protein identities in complex samples.
Highly Sensitive:
Identifies proteins as low as 50 fmol.
Validation Support:
Ensures antibodies isolate the correct targets.
Protein Variants
Detect amino acid substitutions and isobaric variations with single-molecule resolution, uncovering critical insights into health and disease.
Amino Acid Changes:
Differentiates between single amino acid substitutions (SAAS).
Isobaric Resolution:
Distinguishes similar residues such as leucine and isoleucine.
Modification Recognition:
Identifies post-translational modifications with unique kinetic signatures.
Post-Translational Modification Analysis
Precisely analyze proteoforms and post-translational modifications to gain deeper functional insights into protein regulation and activity.
Modification Mapping:
Detects phosphorylation, methylation, and acetylation.
Proteoform Insights:
Distinguishes functionally relevant protein variants.
Quantification Power:
Measures relative PTM abundance.
Antibody Sequencing and Characterization
Gain deep insights into antibody specificity, affinity, and purity. This advanced approach ensures precise targeting and maximized efficacy in therapeutic development.
Binding Specificity:
Verifies antibody interaction with target antigens.
Identify Interactions:
Detect Binding Partners from Immunoprecipitation.
Purity Assessment:
Detects contaminants that impact performance.
Biomarker Identification
Uncover disease biomarkers with single-molecule precision. Gain deeper disease insights through advanced proteomic analysis.
Protein Characterization:
Provides deeper insights into biomarker function.
Precision Detection:
Identifies biomarkers missed by traditional methods.
Multiomic Integration:
Connects proteomic data with genomic and transcriptomic insights.
Next-Gen Single-Molecule Protein Sequencing Technology
Harness kinetic signatures to sequence proteins and detect proteome changes. Quantum-Si’s NGPS™ simplifies sequencing compared to Edman degradation, dives deeper than mass spectrometry with single-molecule resolution, and detects amino acid-level changes missed by immunoassays, making it a powerful tool for identifying protein variants and modifications.
Single-Molecule Resolution:
Captures amino acid sequences with unmatched detail.
Modification Detection:
Identifies post-translational changes in real time.
Broad Applicability:
Supports research in biomarker discovery, disease mechanisms, and drug development.-
Streamlined Workflow:
Minimizes reliance on antibodies and mass spectrometry.
See the Power of Our Platform
Unleash the Power of Protein Barcoding in Drug Development
Quantum-Si’s Platinum® Pro is revolutionizing proteomics in pharmaceutical development with protein barcoding, enabling multiplexed protein variant screening and characterization with faster assay speeds and enhanced throughput.
Accelerated Drug Delivery Development:
Streamlines screening of delivery vehicles like lipid nanoparticles (LNPs) and adeno-associated virus (AAV) capsids in vivo, enhancing precision and speed in discovery programs.
Comprehensive Variant Analysis:
Enables precise tracking and characterization of protein variants from CRISPR and directed evolution, supporting targeted therapy development.
Enhanced Protein Interaction Studies:
Provides in-depth analysis of protein trafficking and interactions, offering crucial insights into cellular mechanisms for drug development.
NEXT-GENERATION PROTEIN
SEQUENCING TECHNOLOGY
INNOVATION LEADERSHIP
See Analyst Report
2023 PROTEOMICS
COMPANY OF THE YEAR
INNOVATION BY
DESIGN 2023
About Quantum-Si
Founded in 2013, Quantum-Si is pioneering the post-genomic era by making protein sequencing accessible. Their flagship products, Platinum® and Platinum® Pro are the world’s first Next-Generation Protein Sequencers™, enabling single-molecule, single-amino-acid resolution.
By integrating biology, chemistry, and artificial intelligence, Quantum-Si empowers researchers to study proteins at an unprecedented scale. This innovation is driving groundbreaking advancements in scientific research and drug development.
Publications
Preprint Publication
Protein Barcoding and Next-Generation Protein Sequencing for Multiplexed Protein Selection, Analysis, and Tracking
Preprint Publication
Protein Sequencing With Single-Amino Acid Resolution Discerns Peptides That Discriminate Tropomyosin Proteoforms
Preprint Publication
Detecting Amino Acid Variants Using Next-Generation Protein
Sequencing (NGPS)
Publication
Real-Time Dynamic Single-Molecule Protein Sequencing on an
Integrated Semiconductor Device
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