Beyond the Genome: Unraveling Protein Variability with Quantum-Si’s Next-Generation Protein Sequencing™ Technology


Next-generation protein sequencing is a transformational tool for protein science to unlock new insights into the function of proteins in health and diseases. Quantum-Si’s Platinum® technology brings the insights of protein sequencing to every lab with a space-friendly benchtop instrument, a simple end-to-end workflow, and single-molecule resolution that enables detection of protein variants and modifications. To demonstrate the versatility of this core methodology and its kinetic principles across a variety of proteins, we sequenced three variants of SARS-CoV-2 spike proteins: Alpha, Delta, and Omicron. Using Platinum, we successfully discriminated two single amino acid substitutions among these variants, effectively distinguishing them from one another.