Peptide Barcodes for Next-Generation Protein Sequencing™

Summary

Discover the power of peptide barcoding with Quantum-Si’s NGPS on the Platinum® instrument. This innovative technology combines the accessibility of DNA-based methods with the versatility of peptide barcoding. By attaching peptides to macromolecular linkers and employing dye-labeled recognizers and aminopeptidases, researchers can generate distinct kinetic signatures for each peptide, enabling high-confidence sequence alignment. Explore our application note for criteria on peptide barcode design, library generation methods, and practical examples of how peptide barcodes revolutionize protein screening, including a 300-fold enrichment in nanobody abundance after positive selection using peptide barcodes.