The End-to-End Solution for Protein Insights
Next-Gen Protein Sequencing™ (NGPS™) delivers single-molecule precision for protein insights with an approachable workflow on a benchtop instrument.
Learn More About Platinum®Single-molecule Protein Sequencing at Your Fingertips
NGPS is made accessible with sequencing and library prep kits.
Our end-to-end solution includes everything you need to prepare libraries, sequence proteins, and analyze results. Every lab can quickly and accurately identify proteins with a simple workflow that makes data interpretation and protein insights accessible.
How it Works
NGPS identifies proteins using unique kinetic signatures based on the binding kinetics of amino acid recognition events. Library preparation and sequencing kits contain reagents to digest and functionalize proteins and immobilize peptides on sequencing chips.
Platinum® sequences individual peptides by capturing the florescent signal from each N-terminal amino acid (NAA) binding event. Aminopeptidases cleave each N-terminal amino acid, exposing the next for recognition, and the process repeats until the whole peptide is sequenced.
Prepare proteins for single-molecule sequencing
Sequence proteins with single-amino acid resolution
Analyze protein sequencing data with ease
Library Preparation Kits
Library prep kits contain reagents to digest and functionalize proteins and immobilize peptides for sequencing.
The Platinum library prep kit offers reagents and workflow to accommodate a broader range of protein characteristics for sequencing.
Improved Chemistry
Reduces the required sample input fivefold
Optimized Protocol
Target protein guidelines maximize insights from challenging samples
Easy-to-Use Solution
Sequencing-ready libraries with less than two hours hands-on time
Protein Sequencing Kits
Protein sequencing kits bring advanced protein insights into focus with ready-to-sequence chips, recognizers, and aminopeptidases.
The Platinum Sequencing Kit enables researchers to look deeper at protein variation with improved peptide alignments and deeper coverage.
Enhanced Insight
The power of our single-amino acid resolution platform is amplified with the addition of aspartic acid (D) recognition. Explore protein functions in health and disease.
Simplified Workflow
Accelerating results with less hands-on time and AI-powered analysis tools for elevated protein insights, making protein sequencing more accessible.
Progressive Innovation
Our latest recognizer set expands access to protein characterization and amino acid variation to accelerate your next breakthrough.
The Power of Next-Gen Protein Sequencing™
With the power of the Platinum V3 sequencing kit, researchers can look deeper at protein variation
with improved peptide alignments and deeper coverage. Protein identification and inference powered by kinetic signatures is amplified by the addition of aspartic acid (D) recognition, our kinetic database, and AI-powered software model driving confidence for protein identification
Our V3 recognizer set expands access to the amino acid diversity in the human proteome by more than two-fold since published in Science, 2022.
Aspartic acid (D) accounts for nearly 5% of amino acids where the D recognizer — together with improved performance of LIV, NQ, and R recognizers — elevates the ability to explore the human proteome with increased coverage and value to maximize your research.
Explore our resources to discover how Next-Generation Protein Sequencing with Platinum can enhance your protein research:
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Library Preparation Kit — DATA SHEET
The Platinum instrument, kits, and software contain everything you need to prepare, sequence, and analyze proteins. Library preparation is the initial step in Quantum-Si’s Next-Generation Protein Sequencing workflow.
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Next-Generation Protein Sequencing Kit — DATA SHEET
The Platinum instrument, kits, and software contain everything you need to prepare, sequence, and analyze proteins. Sequencing Kit is the second step in Quantum-Si’s Next-Generation Protein Sequencing workflow.
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Protein Sequencing With Single-Amino Acid Resolution Discerns Peptides That Discriminate Tropomyosin Proteoforms — PREPRINT
In this study, Gloria Sheynkman and her team evaluated the ability of the recently released Platinum single-molecule protein sequencer to detect proteoform-informative peptides. Platinum employs fluorophore-labeled recognizers that reversibly bind to cognate N-terminal amino acids (NAAs), enabling polypeptide sequencing within nanoscale apertures of a semiconductor chip that can accommodate single peptide molecules.
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Real-Time Dynamic Single-Molecule Protein Sequencing — PUBLICATION
This article, published in Science in 2022, illustrates how the study of the proteome would benefit greatly from methods to directly sequence and digitally quantify proteins and detect posttranslational modifications with single-molecule sensitivity.
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Real-Time Dynamic Single-Molecule Protein Sequencing — BROCHURE
Since our groundbreaking debut in Science in 2022, Quantum-Si has been at the forefront of protein sequencing innovation. Our commitment to progressive innovation has led to significant advancements in our Next-Generation Protein Sequencing™ technology.